Potential role for mucosal IgA in modulating Haemonchus contortus adult worm infection in sheep

Hernández, J.N., Hernández, A., Stear, M., Conde-Felipe, M., Rodríguez, E., Piedrafita, D. and González, J.F. (2016) Potential role for mucosal IgA in modulating Haemonchus contortus adult worm infection in sheep. Veterinary Parasitology, 223, pp. 153-158. (doi: 10.1016/j.vetpar.2016.04.022) (PMID:27198794)

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Abstract

Haemonchus contortus (H. contortus) is a haematophagous parasite which causes important economic losses in small ruminants. On the island of Gran Canaria, two sheep breeds coexist which differ in their susceptibility to the infection with H. contortus; the resistant Canaria Hair Breed (CHB) sheep and the susceptible Canaria Sheep (CS) breed. The major target of resistance mechanisms in CHB sheep are directed to the adult parasite stage, reducing the worm burden, and decreased length and fecundity of surviving worms. Mucosal IgA (mIgA) has been shown to be an important regulator of immunity in Haemonchus and Teladorsagia infections; through correlations with larval stages where such mechanisms as antibody-dependent cell cytotoxicity and enzyme inhibition may mediate resistance. Here for the first time, we demonstrate a significant negative correlation between mIgA and adult worm length and fecundity only in the resistant CHB sheep. In contrast, and as reported in other sheep breeds, mIgA was only negatively correlated against the larval stage in the more susceptible CS breed. This study suggests mIgA may play a role in resistance to both larval and adult stages.

Item Type:Articles
Additional Information:This trial was supported by Canary Government grant, Agencia Canaria de Investigación, Innovación y Sociedad de la Información y Fondo Europeo de Desarrollo Regional (FEDER) (PI 2007/036), Spanish National grant(AGL2009/09985) and Fondo Social Europeo (FSE). A
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stear, Professor Mike
Authors: Hernández, J.N., Hernández, A., Stear, M., Conde-Felipe, M., Rodríguez, E., Piedrafita, D., and González, J.F.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Parasitology
Publisher:Elsevier
ISSN:0304-4017
ISSN (Online):1873-2550
Published Online:20 April 2016
Copyright Holders:Copyright © 2016 Elsevier
First Published:First published in Veterinary Parasitology 223:153-158
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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