Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Tarn, M. D., Maneuski, D. , Alexander, R., Brown, N. J., O'Shea, V. , Pimlott, S. L. , Pamme, N. and Archibald, S. J. (2016) Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical Communications, 52(45), pp. 7221-7224. (doi: 10.1039/c6cc00660d) (PMID:27029282)

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Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:O'Shea, Professor Val and Maneuski, Dr Dima and Pimlott, Dr Sally
Authors: Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O'Shea, V., Pimlott, S. L., Pamme, N., and Archibald, S. J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Physics and Astronomy
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:16 March 2016
Copyright Holders:Copyright © 2016 The Royal Society of Chemistry
First Published:First published in Chemical Communication 52(45): 7221-7224
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
600011Experimental Particle PhysicsAnthony DoyleScience & Technologies Facilities Council (STFC)ST/K001205/1P&A - PHYSICS & ASTRONOMY