Filamentous influenza viruses

Dadonaite, B., Vijayakrishnan, S. , Fodor, E., Bhella, D. and Hutchinson, E. C. (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi:10.1099/jgv.0.000535) (PMID:27365089)

Dadonaite, B., Vijayakrishnan, S. , Fodor, E., Bhella, D. and Hutchinson, E. C. (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi:10.1099/jgv.0.000535) (PMID:27365089)

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Abstract

Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarise what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.

Item Type:Articles
Additional Information:BD is funded by a Wellcome Trust studentship [105399/Z/14/Z]; EF is funded by an MRC programme grant [MR/K000241/1]; SV, DB and ECH are funded by core MRC funding to the MRC-University of Glasgow Centre for Virus Research and ECH is funded by an MRC Career Development Award [MR/N008618/1].
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vijayakrishnan, Dr Swetha and Bhella, Professor David and Hutchinson, Dr Edward
Authors: Dadonaite, B., Vijayakrishnan, S., Fodor, E., Bhella, D., and Hutchinson, E. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099
Published Online:30 June 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of General Virology 97(8): 1755-1764
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
703851Functional investigations of the influenza virus proteomeEdward HutchinsonMedical Research Council (MRC)MR/N008618/1MVLS III - CENTRE FOR VIRUS RESEARCH