Ultra High Speed Observations Of Cavitation Derived Microjetting Phenomena

Prentice, P.A. , Burns, J.M., McLean, D., Cuschieri, A., Sibbett, W. and Campbell, P.A. (2005) Ultra High Speed Observations Of Cavitation Derived Microjetting Phenomena. In: 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, Kahuku, HI, USA, 12-15 May 2005, pp. 160-161. ISBN 0780387112 (doi:10.1109/MMB.2005.1548413)

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Abstract

Ultrasound mediated molecular delivery (sonoporation) is a highly attractive route for cancer- and gene-therapy. This has been demonstrated, both in vitro and in animal trials, to achieve a number of critical bioeffects such as apoptosis, lysis and tumour regression. Moreover, it is now accepted that the clinical potential is enhanced when ultrasound contrast agent (UCA) microbubbles are present during insonation. However, the fundamental mechanism of interaction between cell and microbubble during US exposure remains elusive and this hampers attempts to optimise the approach. In addressing this deficiency in our understanding, we designed and constructed a unique apparatus that can optically guide an individual UCA microbubble to a predefined displacement relative to a planar substrate. In parallel with this, we undertook direct observations, via high speed imaging at MHz frame rates. We demonstrate how this approach has allowed us to observe a dynamic microscopic interaction during insonation, that may give rise to membrane permeabilization in biological cells.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sibbett, Professor Wilson and Prentice, Dr Paul
Authors: Prentice, P.A., Burns, J.M., McLean, D., Cuschieri, A., Sibbett, W., and Campbell, P.A.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
College of Science and Engineering > School of Physics and Astronomy
ISBN:0780387112

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