9B-2 Microbubble Interactions at High Mechanical Index: Ultrasound Stimulated Behaviour of SonoVue from Optically Predefined 'Stand-Off' Positions

Burns, J. M., Prentice, P.A. and Campbell, P. A. (2007) 9B-2 Microbubble Interactions at High Mechanical Index: Ultrasound Stimulated Behaviour of SonoVue from Optically Predefined 'Stand-Off' Positions. IEEE Ultrasonics Symposium, New York, NY, USA, 28-31 Oct 2007. pp. 761-764. ISBN 9781424413843 (doi:10.1109/ULTSYM.2007.195)

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Abstract

Introduction of a temporally periodic pressure field within a fluid can induce forced oscillations to bubbles present therein. The resultant [radial] bubble dynamics are a complex function of several parameters, including the driving pressure amplitude, and proximity to nearby boundaries, such as vessel walls, or indeed, other bubbles. Recently, experimentation gauged towards the development of a quantitative understanding of [acoustically] driven bubbles of micrometer dimensions, especially when close to boundaries, has become a challenge of heightened academic and industrial interest. In pursuit of this, the present authors pioneered a new approach to such measurements that exploits optical trapping to locate microbubbles at prescribed displacements from a boundary [1,2]. Here, we extend our previous method and report the first comprehensive study that has observed the dynamical behavior of isolated single micro-bubbles (the commercially available ultrasound contrast agent: SonoVue) that had been optically trapped over a range of well-defined displacements from a rigid boundary. All of the measurements were conducted at a mechanical index (MI) > 3. We noted a distinct variance in micro-bubble behavior across all quiescent radii and stand-off parameter, and also correlated bubble outcome statistics with measured radial dynamics. Finally, we suggest that the procedure outlined can be exploited to design ‘next-generation’ microbubbles with specific response characteristics.

Item Type:Conference or Workshop Item
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Prentice, Dr Paul
Authors: Burns, J. M., Prentice, P.A., and Campbell, P. A.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
ISSN:1051-0117
ISBN:9781424413843

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