The animal trypanosomiases and their chemotherapy: a review

Giordani, F. , Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi:10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

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Abstract

Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Giordani, Dr Federica and Barrett, Professor Michael and Morrison, Dr Liam and De Koning, Professor Harry
Authors: Giordani, F., Morrison, L. J., Rowan, T. G., De Koning, H. P., and Barrett, M. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
ISSN (Online):1469-8161
Published Online:10 October 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Parasitology 143(14):1862-1889
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
701211A new drug discovery pipeline for animal African trypanosomiasisMichael BarrettBiotechnology and Biological Sciences Research Council (BBSRC)BB/N007999/1III - PARASITOLOGY