Pingen, M. , Bryden, S. R. , Pondeville, E., Schnettler, E., Kohl, A. , Merits, A., Fazakerley, J. K., Graham, G. J. and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi: 10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)
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Abstract
Aedes aegypti mosquitoes are responsible for transmitting many medically important viruses such as those that cause Zika and dengue. The inoculation of viruses into mosquito bite sites is an important and common stage of all mosquito-borne virus infections. We show, using Semliki Forest virus and Bunyamwera virus, that these viruses use this inflammatory niche to aid their replication and dissemination in vivo. Mosquito bites were characterized by an edema that retained virus at the inoculation site and an inflammatory influx of neutrophils that coordinated a localized innate immune program that inadvertently facilitated virus infection by encouraging the entry and infection of virus-permissive myeloid cells. Neutrophil depletion and therapeutic blockade of inflammasome activity suppressed inflammation and abrogated the ability of the bite to promote infection. This study identifies facets of mosquito bite inflammation that are important determinants of the subsequent systemic course and clinical outcome of virus infection.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Schnettler, Dr Esther and Bryden, Dr Steven and McKimmie, Dr Clive and Pondeville, Dr Emilie and Pingen, Dr Marieke and Kohl, Professor Alain and Graham, Professor Gerard |
| Authors: | Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A., Merits, A., Fazakerley, J. K., Graham, G. J., and McKimmie, C. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Immunity |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 1074-7613 |
| ISSN (Online): | 1097-4180 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Immunity 44(6):1455-1469 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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