Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome

Gould, G. W. (2016) Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome. Seminars in Cell and Developmental Biology, 53, pp. 64-73. (doi:10.1016/j.semcdb.2015.12.012) (PMID:26721337)

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Abstract

In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles. Contraction of this ring drives ingression of the cleavage furrow, and culminates in the formation of a thin intercellular bridge between the daughter cells. At the centre of this bridge is the midbody, which is thought both to provide a site of attachment for the plasma membrane furrow and act as foci for the spatial and temporal control mechanisms that drive abscission. This review will focus upon recent studies that offer new insight into these events, in particular studies that elaborate on the mechanism of attachment between the furrow plasma membrane and the underlying cytoskeleton, and how dynamic changes in membrane composition might underpin key aspects of cytokinesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn
Authors: Gould, G. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Seminars in Cell and Developmental Biology
Publisher:Elsevier
ISSN:1084-9521
ISSN (Online):1096-3634
Published Online:23 December 2015
Copyright Holders:Copyright © 2015 Elsevier
First Published:First published in Seminars in Cell and Developmental Biology 53:64-73
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
463021Regulation and role of the Exocyst complex in cytokinesis.Gwyn GouldCancer Research UK (CAN-RES-UK)C25017/A9006RI MOLECULAR CELL & SYSTEMS BIOLOGY
562531Investigation of the role of Syntaxin 16 and mVps45 in cytokinesisGwyn GouldCancer Research UK (CAN-RES-UK)13082RI MOLECULAR CELL & SYSTEMS BIOLOGY