Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease

Montaldi, D., Brooks, D.N., McColl, J.H. , Wyper, D., Patterson, J., Barron, E. and McCulloch, J. (1990) Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 53(1), pp. 33-38. (doi: 10.1136/jnnp.53.1.33) (PMID:2303829) (PMCID:PMC1014094)

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Abstract

Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McColl, Professor John
Authors: Montaldi, D., Brooks, D.N., McColl, J.H., Wyper, D., Patterson, J., Barron, E., and McCulloch, J.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Journal of Neurology, Neurosurgery and Psychiatry
Publisher:BMJ Publishing Group
ISSN:0022-3050
ISSN (Online):1468-330X

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