lncRNA/MicroRNA interactions in the vasculature

Ballantyne, M.D., McDonald, R.A. and Baker, A.H. (2016) lncRNA/MicroRNA interactions in the vasculature. Clinical Pharmacology and Therapeutics, 99(5), pp. 494-501. (doi: 10.1002/cpt.355) (PMID:26910520)

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MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-miRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Baker, Professor Andrew and McDonald, Dr Robert
Authors: Ballantyne, M.D., McDonald, R.A., and Baker, A.H.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Clinical Pharmacology and Therapeutics
ISSN (Online):1532-6535
Published Online:31 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Clinical Pharmacology and Therapeutics 99(5): 494-501
Publisher Policy:Reproduced under a Creative Commons License

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