A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery

McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B. and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi: 10.4236/pp.2016.76029)

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Abstract

Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study we implanted stents coated with cicaprost, a prostacyclin analogue with a long plasma half-life and antiproliferative effects on vascular smooth muscle cells, into the iliac arteries of rabbits. At 28-day follow-up we compared neointima formation within the stented vessels and vascular function in adjacent vessels, to assess if cicaprost could reduce restenosis without impairing vessel function. Arteries implanted with cicaprost eluting stents had significantly more neointima compared to bare metal stents. In adjacent segments of artery, endothelium-dependent relaxation was impaired by the cicaprost-eluting stent but vasodilation to an endothelium-independent vasodilator was maintained. We conclude that the presence of the polymer and sub-optimal release of cicaprost from the stent may be responsible for the increased neointma and impaired functional recovery of the endothelium observed. Further experiments should be aimed at optimising release of cicaprost and exploring different stent polymer coatings.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Simon
Authors: McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B., and Kennedy, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Pharmacology and Pharmacy
Publisher:Scientific Publishing
ISSN:2157-9423
ISSN (Online):2157-9431
Published Online:24 June 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Pharmacology and Pharmacy 7(6):226-235
Publisher Policy:Reproduced under a Creative Commons License

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