IBD—what role do proteobacteria play?

Mukhopadhya, I., Hansen, R., El-Omar, E. M. and Hold, G. L. (2012) IBD—what role do proteobacteria play? Nature Reviews Gastroenterology and Hepatology, 9(4), pp. 219-230. (doi: 10.1038/nrgastro.2012.14) (PMID:22349170)

Abstract

The gastrointestinal microbiota has come to the fore in the search for the causes of IBD. This shift has largely been driven by the finding of genetic polymorphisms involved in gastrointestinal innate immunity (particularly polymorphisms in NOD2 and genes involved in autophagy) and alterations in the composition of the microbiota that might result in inflammation (so-called dysbiosis). Microbial diversity studies have continually demonstrated an expansion of the Proteobacteria phylum in patients with IBD. Individual Proteobacteria, in particular (adherent-invasive) Escherichia coli, Campylobacter concisus and enterohepatic Helicobacter, have all been associated with the pathogenesis of IBD. In this Review, we comprehensively describe the various associations of Proteobacteria and IBD. We also examine the importance of pattern recognition in the extracellular innate immune response of the host with particular reference to Proteobacteria, and postulate that Proteobacteria with adherent and invasive properties might exploit host defenses, drive proinflammatory change, alter the intestinal microbiota in favor of dysbiosis and ultimately lead to the development of IBD.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hansen, Dr Richard
• Authors: Mukhopadhya, I., Hansen, R., El-Omar, E. M., and Hold, G. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Nature Reviews Gastroenterology and Hepatology
• Publisher: Nature Publishing Group
• ISSN: 1759-5045
• ISSN (Online): 1759-5053