Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, J.M., Russell, R.K., Berry, S.H., El-Omar, E.M. and Hold, G.L. (2015) The fungal microbiota of de-novo paediatric inflammatory bowel disease. Microbes and Infection, 17(4), pp. 304-310. (doi: 10.1016/j.micinf.2014.12.001) (PMID:25522934) (PMCID:PMC4392392)
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Abstract
Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Russell, Dr Richard and Hansen, Dr Richard |
| Authors: | Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, J.M., Russell, R.K., Berry, S.H., El-Omar, E.M., and Hold, G.L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Microbes and Infection |
| Publisher: | Elsevier |
| ISSN: | 1286-4579 |
| ISSN (Online): | 1769-714X |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Microbes and Infection 17(4):304-310 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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