Holm, S.H., Beech, J.P., Barrett, M.P. and Tegenfeldt, J.O. (2016) Simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(16), pp. 3291-3300. (doi: 10.1039/c6ay00443a)
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Abstract
With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series. With only one inlet and no expensive or complicated pumping mechanisms to run separations we ensure the level of simplicity necessary for field use.
| Item Type: | Articles |
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| Additional Information: | A correction to this article is available at http://dx.doi.org/10.1039/c6ay90099b. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Barrett, Professor Michael |
| Authors: | Holm, S.H., Beech, J.P., Barrett, M.P., and Tegenfeldt, J.O. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Analytical Methods |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1759-9660 |
| ISSN (Online): | 1759-9679 |
| Published Online: | 08 March 2016 |
| Copyright Holders: | Copyright © 2016 The Royal Society of Chemistry |
| First Published: | First published in Analytical Methods 8(16): 3291-3300 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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