Simplifying microfluidic separation devices towards field-detection of blood parasites

Holm, S.H., Beech, J.P., Barrett, M.P. and Tegenfeldt, J.O. (2016) Simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(16), pp. 3291-3300. (doi: 10.1039/c6ay00443a)

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Abstract

With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series. With only one inlet and no expensive or complicated pumping mechanisms to run separations we ensure the level of simplicity necessary for field use.

Item Type:Articles
Additional Information:A correction to this article is available at http://dx.doi.org/10.1039/c6ay90099b.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barrett, Professor Michael
Authors: Holm, S.H., Beech, J.P., Barrett, M.P., and Tegenfeldt, J.O.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Analytical Methods
Publisher:Royal Society of Chemistry
ISSN:1759-9660
ISSN (Online):1759-9679
Published Online:08 March 2016
Copyright Holders:Copyright © 2016 The Royal Society of Chemistry
First Published:First published in Analytical Methods 8(16): 3291-3300
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
599191LAPASOMichael BarrettEuropean Commission (EC)607350III - PARASITOLOGY