Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, D. et al. (2016) Combined effects of smoking and HPV16 in oropharyngeal cancer. International Journal of Epidemiology, 45(3), pp. 752-761. (doi:10.1093/ije/dyw069) (PMID:27197530)

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Abstract

Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Conway, Professor David
Authors: Anantharaman, D., Muller, D. C., Lagiou, P., Ahrens, W., Holcátová, I., Merletti, F., Kjærheim, K., Polesel, J., Simonato, L., Canova, C., Castellsague, X., Macfarlane, T. V., Znaor, A., Thomson, P., Robinson, M., Conway, D. I., Healy, C. M., Tjønneland, A., Westin, U., Ekström, J., Chang-Claude, J., Kaaks, R., Overvad, K., Drogan, D., Hallmans, G., Laurell, G., Bueno-de-Mesquita, H.B., Peeters, P. H., Agudo, A., Larrañaga, N., Travis, R. C., Palli, D., Barricarte, A., Trichopoulou, A., George, S., Trichopoulos, D., Quirós, J.R., Grioni, S., Sacerdote, C., Navarro, C., Sánchez, M.-J., Tumino, R., Severi, G., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Panico, S., Weiderpass, E., Lund, E., Gram, I. T., Riboli, E., Pawlita, M., Waterboer, T., Kreimer, A. R., Johansson, M., and Brennan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:International Journal of Epidemiology
Journal Abbr.:Int J Epidemiol
Publisher:Oxford University Press
ISSN:0300-5771
ISSN (Online):1464-3685
Published Online:19 May 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in International Journal of Epidemiology 45(3): 752-761
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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