Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

Sans Sangorrin, V. and Cronin, L. (2016) Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation. Chemical Society Reviews, 45(8), pp. 2032-2043. (doi:10.1039/C5CS00793C) (PMID:26815081) (PMCID:PMC6057606)

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Abstract

The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cronin, Professor Leroy and Sans Sangorrin, Dr Victor
Authors: Sans Sangorrin, V., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Society Reviews
Publisher:Royal Society of Chemistry
ISSN:0306-0012
ISSN (Online):1460-4744
Published Online:27 January 2016

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
503291Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular LimitLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/H024107/1CHEM - CHEMISTRY
503295Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular LimitLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/H024107/1CHEM - CHEMISTRY
562821Innovative Manufacturing Research Centre for Continuous Manufacturing and Crystallisation (CMAC)Leroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/I033459/1CHEM - CHEMISTRY
571901International Collaboration in Chemistry - Modular microtubular architectures for photo-driven water splittingLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/J00135X/1CHEM - CHEMISTRY
577391Programmable Molecular Metal Oxides (PMMOs) - From Fundamentals to ApplicationLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/J015156/1CHEM - CHEMISTRY
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG
616021Energy and the Physical Sciences: Hydrogen Production using a Proton Electron BufferLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/K023004/1CHEM - CHEMISTRY
621351Synthetic Biology applications to Water Supply and RemediationSteven BeaumontEngineering & Physical Sciences Research Council (EPSRC)EP/K038885/1VICE PRINCIPAL RESEARCH & ENTERPRISE
621352Synthetic Biology applications to Water Supply and RemediationSteven BeaumontEngineering & Physical Sciences Research Council (EPSRC)EP/K038885/1VICE PRINCIPAL RESEARCH & ENTERPRISE
642321Sustainable and resilient water systems for small communities.William SloanEngineering & Physical Sciences Research Council (EPSRC)EP/K038885/1ENG - ENGINEERING INFRASTRUCTURE & ENVIR
633821A Digital DNA Nano Writer (DNA NanoFab)Leroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/L015668/1CHEM - CHEMISTRY
646611Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/L023652/1CHEM - CHEMISTRY
561223Plug'n Play Photosynthetic for Rubisco Independent FuelsLeroy CroninBiotechnology and Biological Sciences Research Council (BBSRC)BB/M011267/1CHEM - CHEMISTRY
630101EVOPROGLeroy CroninEuropean Commission (EC)610730CHEM - CHEMISTRY
599451Microscale Chemically Reactive Electronic AgentsLeroy CroninEuropean Commission (EC)FP7 ICT MICRE31CHEM - CHEMISTRY
685741SMARTPOM: Artificial-Intelligence Driven Discovery and Synthesis of Polyoxometalate ClustersLeroy CroninEuropean Research Council (ERC)670467CHEM - CHEMISTRY