Carr, R., Di Bari, L., Lo Piano, S., Parker, D., Peacock, R. D. and Sanderson, J. M. (2012) A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence. Dalton Transactions, 41(42), pp. 13154-13158. (doi: 10.1039/c2dt30143a) (PMID:23023320)
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Abstract
Reversible and selective binding of a dynamically racemic europium(III) complex to α1-acid glycoprotein and α1-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α1-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Peacock, Dr Robert |
| Authors: | Carr, R., Di Bari, L., Lo Piano, S., Parker, D., Peacock, R. D., and Sanderson, J. M. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Dalton Transactions |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1477-9226 |
| ISSN (Online): | 1477-9234 |
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