Genome sequence of canine herpesvirus

Papageorgiou, K. V., Suárez, N. M., Wilkie, G. S., McDonald, M., Graham, E. M. and Davison, A. (2016) Genome sequence of canine herpesvirus. PLoS ONE, 11(5), e0156015. (doi:10.1371/journal.pone.0156015) (PMID:27213534) (PMCID:PMC4877106)

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Abstract

Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp) and a unique short sequence (7.7 kbp) that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively). The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilkie, Dr Gavin and Suarez, Dr Nicolas and Graham, Dr Libby and McDonald, Mr Mike and Davison, Professor Andrew
Authors: Papageorgiou, K. V., Suárez, N. M., Wilkie, G. S., McDonald, M., Graham, E. M., and Davison, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Published Online:23 May 2016
Copyright Holders:Copyright © 2016 Papageorgiou et al.
First Published:First published in PLoS ONE 11(5):e0156015
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH