Adipocytes, aldosterone and obesity-related hypertension

Nguyen Dinh Cat, A., Friederich-Persson, M., White, A. and Touyz, R. M. (2016) Adipocytes, aldosterone and obesity-related hypertension. Molecular Endocrinology, 57(1), F7-F21. (doi:10.1530/JME-16-0025) (PMID:27357931)

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Abstract

Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions. Plasma aldosterone levels are positively correlated with body mass index and weight loss in obese patients is reported to be accompanied by decreased aldosterone levels. This suggests a relationship between adipose tissue and the production/secretion of aldosterone. Aldosterone is synthesized principally by the adrenal glands, but its production may be regulated by many factors, including factors secreted by adipocytes. In addition, studies have reported local synthesis of aldosterone in extra-adrenal tissues, including adipose tissue. Experimental studies have highlighted a role for adipocyte-secreted aldosterone in the pathogenesis of obesity-related cardiovascular complications via the mineralocorticoid receptor. This review focuses on how aldosterone secretion may be influenced by adipose tissue and the importance of these mechanisms in the context of obesity-related hypertension.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:White, Dr Anna and Friederich-Persson, Dr Malou and Nguyen Dinh Cat, Dr Aurelie and Touyz, Professor Rhian
Authors: Nguyen Dinh Cat, A., Friederich-Persson, M., White, A., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Molecular Endocrinology
Publisher:The Endocrine Society
ISSN:0888-8809
ISSN (Online):1944-9917
Published Online:01 July 2016
Copyright Holders:Copyright © 2016 The Endocrine Society
First Published:First published in Molecular Endocrinology 57(1):F7-F21
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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