Reactive oxygen species and hydrogen peroxide generation in cell migration

Rudzka, D. A., Cameron, J. M. and Olson, M. F. (2015) Reactive oxygen species and hydrogen peroxide generation in cell migration. Communicative and Integrative Biology, 8(5), e1074360. (doi: 10.1080/19420889.2015.1074360) (PMID:27066166) (PMCID:PMC4802769)

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Abstract

Directional cell migration is a complex process that requires spatially and temporally co-ordinated regulation of actin cytoskeleton dynamics. In response to external cues, signals are transduced to elicit cytoskeletal responses. It has emerged that reactive oxygen species, including hydrogen peroxide, are important second messengers in pathways that influence the actin cytoskeleton, although the identities of key proteins regulated by hydrogen peroxide are largely unknown. We recently showed that oxidation of cofilin1 is elevated in migrating cells relative to stationary cells, and that the effect of this post-translational modification is to reduce cofilin1-actin binding and to inhibit filamentous-actin severing by cofilin1. These studies revealed that cofilin1 regulation by hydrogen peroxide contributes to directional cell migration, and established a template for discovering additional proteins that are regulated in an analogous manner.

Item Type:Articles
Additional Information:Funding from Cancer Research UK (A18276).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cameron, Mrs Jenifer and Rudzka, Dominika Agnieszka and Olson, Professor Michael
Authors: Rudzka, D. A., Cameron, J. M., and Olson, M. F.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Communicative and Integrative Biology
Publisher:Taylor and Francis
ISSN:1942-0889
ISSN (Online):1942-0889
Published Online:30 December 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Communicative and Integrative Biology 8(5):e1074360
Publisher Policy:Reproduced under a creative commons license

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