Abattoir-based estimates of mycobacterial infections in Cameroon

Egbe, N.F. et al. (2016) Abattoir-based estimates of mycobacterial infections in Cameroon. Scientific Reports, 6, 24320. (doi: 10.1038/srep24320) (PMID:27075056) (PMCID:PMC4830956)

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Abstract

Mycobacteria cause major diseases including human tuberculosis, bovine tuberculosis and Johne’s disease. In livestock, the dominant species is M. bovis causing bovine tuberculosis (bTB), a disease of global zoonotic importance. In this study, we estimated the prevalence of Mycobacteria in slaughter cattle in Cameroon. A total of 2,346 cattle were examined in a cross-sectional study at four abattoirs in Cameroon. Up to three lesions per animal were collected for further study and a retropharyngeal lymph node was collected from a random sample of non-lesioned animals. Samples were cultured on Lowenstein Jensen media and the BACTEC MGIT 960 system, and identified using the Hain® Genotype kits. A total of 207/2,346 cattle were identified with bTB-like lesions, representing 4.0% (45/1,129), 11.3% (106/935), 23.8% (38/160) and 14.8% (18/122) of the cattle in the Bamenda, Ngaoundere, Garoua and Maroua abattoirs respectively. The minimum estimated prevalence of M. bovis was 2.8% (1.9–3.9), 7.7% (6.1–9.6), 21.3% (15.2–28.4) and 13.1% (7.7–20.4) in the four abattoirs respectively. One M. tuberculosis and three M. bovis strains were recovered from non-lesioned animals. The high prevalence of M. bovis is of public health concern and limits the potential control options in this setting without a viable vaccine as an alternative.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kelly, Mr Robert
Authors: Egbe, N.F., Muwonge, A., Ndip, L., Kelly, R.F., Sander, M., Tanya, V., Ngwa, Ngu, V., Handel, I.G., Novak, A., Ngandalo, R., Mazeri, S., Morgan, K.L., Asuquo, A., and de C. Bronsvoort, B.M.
Subjects:Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Published Online:14 April 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Scientific Reports 6:24320
Publisher Policy:Reproduced under a Creative Commons License

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