Mahinrad, S., Jukema, J. W., van Heemst, D. v., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M. and Sabayan, B. (2016) 10-Second heart rate variability and cognitive function in old age. Neurology, 86(12), pp. 1120-1127. (doi: 10.1212/wnl.0000000000002499) (PMID:26888988)
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Publisher's URL: http://dx.doi.org/10.1212/wnl.0000000000002499
Abstract
Objective: To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. Methods: We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domains were assessed at baseline and repeated during a mean follow-up period of 3.2 years. Results: Lower HRV at baseline was associated with worse performance in reaction time (mean difference between low third vs high third of HRV = 1.96 seconds, 95% confidence interval [CI] 0.20 to 3.71) and processing speed (−0.57 digits coded, 95% CI −1.09 to −0.05). During follow-up, participants with lower HRV had a steeper decline in processing speed (mean annual change between low third vs high third of HRV = −0.16 digits coded, 95% CI −0.28 to −0.04). There was no difference in annual changes of reaction time or immediate and delayed memory among HRV thirds during follow-up. All these associations remained unchanged after adjustment for medications, cardiovascular risk factors, and comorbidities. Conclusions: Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Macfarlane, Professor Peter and Clark, Mrs Elaine |
Authors: | Mahinrad, S., Jukema, J. W., van Heemst, D. v., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M., and Sabayan, B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Neurology |
Publisher: | American Academy of Neurology |
ISSN: | 0028-3878 |
ISSN (Online): | 1526-632X |
Published Online: | 22 March 2016 |
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