Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings

Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G. and Mark, P. B. (2017) Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings. European Radiology, 27(1), pp. 315-324. (doi: 10.1007/s00330-016-4288-4) (PMID:27053260)

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Abstract

Objectives: Left ventricular mass (LVM) at cardiac magnetic resonance imaging (CMR) is a frequent end point in clinical trials in nephrology. Trial participants with end stage renal disease (ESRD) may have a greater frequency of incidental findings (IF). We retrospectively investigated prevalence of IF in previous research CMR and reviewed their subsequent impact on participants. Methods: Between 2002 and 2006, 161 ESRD patients underwent CMR in a transplant assessment study. Images were used to assess LV mass and function. In the current study a radiologist reviewed the scans for IF. Review of patient records determined the subsequent clinical significance of IF. Results: There were 150 IF in 95 study participants. Eighty-four (56 %) were new diagnoses. One hundred and two were non-cardiac. Fifteen were suspicious of malignancy. There was a clinically significant IF for 14.9 % of the participants. In six cases earlier identification of an IF may have improved quality of life or survival. Conclusions: Without radiology support clinically important IF may be missed on CMR. Patients undergoing CMR in trials should be counselled about the frequency and implications of IF. Patients with ESRD have a higher prevalence of IF than reported in other populations. Nephrology studies require mechanisms for radiologist reporting and strategies for dealing with IF.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Dr Rajan and Rutherford, Dr Elaine and Roditi, Dr Giles and Mark, Dr Patrick and Jardine, Professor Alan
Authors: Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:European Radiology
Publisher:Springer Berlin Heidelberg
ISSN:0938-7994
ISSN (Online):1432-1084
Published Online:07 April 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in European Radiology 27(1): 315-324
Publisher Policy:Reproduced under a Creative Commons License

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