Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: associations of myocardial strain with myocardial region, age, and sex

Mangion, K. et al. (2016) Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: associations of myocardial strain with myocardial region, age, and sex. Journal of Magnetic Resonance Imaging, 44(5), pp. 1197-1205. (doi:10.1002/jmri.25280) (PMID:27104306) (PMCID:PMC5082565)

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Abstract

Purpose: We assessed myocardial strain using cine displacement encoding with stimulated echoes (DENSE) using 1.5T and 3.0T MRI in healthy adults. Materials and Methods: Healthy adults without any history of cardiovascular disease underwent MRI at 1.5T and 3.0T within 2 days. The MRI protocol included b-SSFP, 2D cine-EPI-DENSE, and late gadolinium enhancement in subjects>45 years. Acquisitions were divided into 6 segments, global and segmental peak longitudinal and circumferential strain were derived and analyzed by field strength, age and gender. Results: 89 volunteers (mean age 44.8 ± 18.0 years, range: 18-87 years) underwent MRI at 1.5T, and 88 of these subjects underwent MRI at 3.0T (1.4±1.4 days between the scans). Compared with 3.0T, the magnitudes of global circumferential (-19.5±2.6% vs. -18.47±2.6%; p=0.001) and longitudinal (-12.47±3.2% vs -10.53±3.1%; p=0.004) strain were greater at 1.5T. At 1.5T, longitudinal strain was greater in females than in males: -10.17±3.4% vs. -13.67±2.4%; p=0.001. Similar observations occurred for circumferential strain at 1.5T (-18.72±2.2% vs. -20.10±2.7%; p=0.014) and at 3.0T (-17.92 ± 1.8% vs -19.1 ± 3.1%; p=0.047). At 1.5T, longitudinal and circumferential strain were not associated with age after accounting for sex (longitudinal strain p= 0.178, circumferential strain p= 0.733). At 3.0T, longitudinal and circumferential strain were associated with age. (p<0.05) Longitudinal strain values were greater in the apico-septal, basal-lateral and mid-lateral segments and circumferential strain in the inferior, infero-lateral and antero-lateral LV segments. Conclusion: Myocardial strain parameters as revealed by cine-DENSE at different MRI field strengths were associated with myocardial region, age and sex.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Mccomb, Dr Christie and Carrick, Dr David and Rauhalammi, Mr Samuli and Clerfond, Dr Guillaume and Corcoran, Dr David and Mangion, Dr Kenneth and Woodward, Miss Rosemary and McClure, Dr John and Radjenovic, Dr Aleksandra
Authors: Mangion, K., Clerfond, G., Mccomb, C., Carrick, D., Rauhalammi, S. M., McClure, J., Corcoran, D. S., Woodward, R., Orchard, V., Radjenovic, A., Zhong, X., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Magnetic Resonance Imaging
Publisher:Wiley
ISSN:1053-1807
ISSN (Online):1522-2586
Published Online:22 April 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Magnetic Resonance Imaging 2016
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
662681"First steps towards modelling myocardial infarction (a computed MI Physiome): A case-control study of novel biomechanical parameters in acute MI survivors with left ventricular dysfunction."Colin BerryBritish Heart Foundation (BHF)PG/14/64/31043RI CARDIOVASCULAR & MEDICAL SCIENCES
699321Myocardial strain measurements in survivors of acute ST-elevation myocardial infarction: implementation and prognostic significance of novel magnetic resonance imaging methods.Colin BerryBritish Heart Foundation (BHF)FS/15/54/31639RI CARDIOVASCULAR & MEDICAL SCIENCES