Mangion, K. et al. (2016) Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: associations of myocardial strain with myocardial region, age, and sex. Journal of Magnetic Resonance Imaging, 44(5), pp. 1197-1205. (doi: 10.1002/jmri.25280) (PMID:27104306) (PMCID:PMC5082565)
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Abstract
Purpose: We assessed myocardial strain using cine displacement encoding with stimulated echoes (DENSE) using 1.5T and 3.0T MRI in healthy adults. Materials and Methods: Healthy adults without any history of cardiovascular disease underwent MRI at 1.5T and 3.0T within 2 days. The MRI protocol included b-SSFP, 2D cine-EPI-DENSE, and late gadolinium enhancement in subjects>45 years. Acquisitions were divided into 6 segments, global and segmental peak longitudinal and circumferential strain were derived and analyzed by field strength, age and gender. Results: 89 volunteers (mean age 44.8 ± 18.0 years, range: 18-87 years) underwent MRI at 1.5T, and 88 of these subjects underwent MRI at 3.0T (1.4±1.4 days between the scans). Compared with 3.0T, the magnitudes of global circumferential (-19.5±2.6% vs. -18.47±2.6%; p=0.001) and longitudinal (-12.47±3.2% vs -10.53±3.1%; p=0.004) strain were greater at 1.5T. At 1.5T, longitudinal strain was greater in females than in males: -10.17±3.4% vs. -13.67±2.4%; p=0.001. Similar observations occurred for circumferential strain at 1.5T (-18.72±2.2% vs. -20.10±2.7%; p=0.014) and at 3.0T (-17.92 ± 1.8% vs -19.1 ± 3.1%; p=0.047). At 1.5T, longitudinal and circumferential strain were not associated with age after accounting for sex (longitudinal strain p= 0.178, circumferential strain p= 0.733). At 3.0T, longitudinal and circumferential strain were associated with age. (p<0.05) Longitudinal strain values were greater in the apico-septal, basal-lateral and mid-lateral segments and circumferential strain in the inferior, infero-lateral and antero-lateral LV segments. Conclusion: Myocardial strain parameters as revealed by cine-DENSE at different MRI field strengths were associated with myocardial region, age and sex.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mccomb, Dr Christie and Carrick, Dr David and Rauhalammi, Mr Samuli and Corcoran, Dr David and Clerfond, Dr Guillaume and Mangion, Dr Kenneth and Woodward, Miss Rosemary and Berry, Professor Colin and McClure, Dr John and Radjenovic, Dr Aleksandra |
| Authors: | Mangion, K., Clerfond, G., Mccomb, C., Carrick, D., Rauhalammi, S. M., McClure, J., Corcoran, D. S., Woodward, R., Orchard, V., Radjenovic, A., Zhong, X., and Berry, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Magnetic Resonance Imaging |
| Publisher: | Wiley |
| ISSN: | 1053-1807 |
| ISSN (Online): | 1522-2586 |
| Published Online: | 22 April 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Journal of Magnetic Resonance Imaging 2016 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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