Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

McClelland, R. et al. (2016) Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. Aging, 8(5), pp. 1135-1149. (doi:10.18632/aging.100948) (PMID:27132985) (PMCID:PMC4931858)

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Abstract

Background: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. Results: We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. Conclusions: Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Demou, Dr Evangelia and Mohammed, Dr Suhaib and Caslake, Professor Muriel and Shiels, Professor Paul and Cooney, Mrs Josephine and MacDonald, Professor Ewan and McGuinness, Dr Dagmara and Bakhshi, Mrs Andisheh
Authors: McClelland, R., Christensen, K., Mohammed, S., McGuinness, D., Cooney, J., Bakhshi, A., Demou, E., Macdonald, E., Caslake, M., Stenvinkel, P., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO Unit
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Aging
Publisher:Impact Journals
ISSN:1945-4589
ISSN (Online):1945-4589
Published Online:26 April 2016
Copyright Holders:Copyright © 2016 McClelland et al
First Published:First published in Aging 8(5): 1135-1149
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
620221MRC SPHSU/GU Transfer FellowshipsLaurence MooreMedical Research Council (MRC)MC_PC_13027IHW - MRC/CSO SPHU