Genetic counseling for childhood tumors and inherited cancer-predisposing syndromes

Tobias, E. (2016) Genetic counseling for childhood tumors and inherited cancer-predisposing syndromes. In: Carachi, R. and Grosfeld, J. (eds.) Surgery of Childhood Tumours. Springer-Verlag: Berlin, pp. 51-66. ISBN 9783662485880 (doi:10.1007/978-3-662-48590-3_5)

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Publisher's URL: http://www.springer.com/gb/book/9783662485880

Abstract

In this chapter, the general principles regarding the genetic causes of childhood tumors are discussed. In addition, the main features of the more common genetic syndromes associated with childhood tumors are described, together with an outline of the underlying molecular mechanisms. Point mutations and also larger, chromosomal, changes are described. Practical advice is given for genetic counseling in general and more specific advice is provided for many of the syndromes. Details of helpful online sources of the latest information regarding cancer-related syndromes are given. Furthermore, to facilitate rapid access to such information, a freely accessible website is provided by the author, at www.essentialmedgen.com, that acts as a guide and portal to 70 international online resources, categorized according to content. Each internet resource contains detailed, up-to-date information regarding clinical details, testing laboratories, genes, proteins, analysis tools or patient support groups. Such information will provide a useful supplement to that contained herein.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Carachi, Professor Robert and Tobias, Professor Edward
Authors: Tobias, E.
Subjects:Q Science > QH Natural history > QH426 Genetics
R Medicine > RB Pathology
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Publisher:Springer-Verlag
ISBN:9783662485880

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