Accuracy of circulating adiponectin for predicting gestational diabetes: a systematic review and meta-analysis

Iliodromiti, S., Sassarini, J., Kelsey, T. W., Lindsay, R. S. , Sattar, N. and Nelson, S. M. (2016) Accuracy of circulating adiponectin for predicting gestational diabetes: a systematic review and meta-analysis. Diabetologia, 59(4), pp. 692-699. (doi: 10.1007/s00125-015-3855-6) (PMID:26768001) (PMCID:PMC4779132))

Abstract

Aims/hypothesis: Universal screening for gestational diabetes mellitus (GDM) has not been implemented, and this has had substantial clinical implications. Biomarker-directed targeted screening might be feasible. We sought to determine the accuracy of circulating adiponectin for early prediction of GDM. Methods: A systematic review and meta-analysis of the literature to May 2015 identified studies in which circulating adiponectin was measured prior to a diagnosis of GDM. Data on diagnostic accuracy were synthesised by bivariate mixed effects and hierarchical summary receiver operating characteristic (HSROC) models. Results: Thirteen studies met the eligibility criteria, 11 of which (2,865 women; 794 diagnosed with GDM) had extractable data. Circulating adiponectin had a pooled diagnostic odds ratio (DOR) of 6.4 (95% CI 4.1, 9.9), a summary sensitivity of 64.7% (95% CI 51.0%, 76.4%) and a specificity of 77.8% (95% CI 66.4%, 86.1%) for predicting future GDM. The AUC of the HSROC was 0.78 (95% CI 0.74, 0.81). First trimester adiponectin had a pooled sensitivity of 60.3% (95% CI 46.0%, 73.1%), a specificity of 81.3% (95% CI 71.6%, 88.3%) and a DOR of 6.6 (95% CI 3.6, 12.1). The AUC was 0.79 (95% CI 0.75, 0.82). Pooled estimates were similar after adjustment for age, BMI or specific GDM diagnostic threshold. Conclusions/interpretation: Pre-pregnancy and early pregnancy measurement of circulating adiponectin may improve the detection of women at high risk of developing GDM. Prospective evaluation of the combination of adiponectin and maternal characteristics for early identification of those who do and do not require OGTT is warranted.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lindsay, Dr Robert and Iliodromiti, Dr Stamatina and Nelson, Professor Scott and Sattar, Professor Naveed
• Authors: Iliodromiti, S., Sassarini, J., Kelsey, T. W., Lindsay, R. S., Sattar, N., and Nelson, S. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Diabetologia
• Publisher: Springer
• ISSN: 0012-186X
• ISSN (Online): 1432-0428
• Published Online: 14 January 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Diabetologia 59:692-699
• Publisher Policy: Reproduced under a creative commons license