Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells

Becker, T. C., Coley, S. M., Wherry, E. J. and Ahmed, R. (2005) Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. Journal of Immunology, 174(3), pp. 1269-1273. (doi:10.4049/​jimmunol.174.3.1269) (PMID:15661882)

Full text not currently available from Enlighten.

Abstract

Proliferative renewal of memory CD8 T cells is essential for maintaining long-term immunity. In this study, we examined the contributions that various tissue microenvironments make toward the homeostatic proliferation of Ag-specific memory CD8 T cells. We found that dividing memory T cells were present in both lymphoid and nonlymphoid tissues. However, the bone marrow was the preferred site for proliferation and contained a major pool of the most actively dividing memory CD8 T cells. Adoptive transfer studies indicated that memory cells migrated through the bone marrow and divided there preferentially. These results show that the bone marrow is not only the source of stem cells for generating naive T cells but also provides the necessary signals for the self-renewal of memory T cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coley, Dr Shana
Authors: Becker, T. C., Coley, S. M., Wherry, E. J., and Ahmed, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Publisher:American Association of Immunologists
ISSN:0022-1767
ISSN (Online):1550-6606

University Staff: Request a correction | Enlighten Editors: Update this record