Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis

Akcal, A., Yılmaz, S. G., Lappin, D. F. and Eğrilmez, S. (2016) Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis. Journal of Clinical Periodontology, 43(8), pp. 637-645. (doi:10.1111/jcpe.12555) (PMID:27028890)

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Abstract

Objectives This study aimed to investigate the levels of eleven oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis (IU) and systemically healthy individuals (H) with or without gingival inflammation. Materials and Methods Twenty-one patients with IU (n=21), and twenty-two systemically healthy individuals (n=22) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by ELISA. Bacteria gene copy numbers were determined by qPCR on plaque microbial DNA preparations. Results According to two-step cluster analysis, ANOVA and t-test: GCF, serum and salivary TNF-α, IL-17A, IL-17A/E; GCF and serum IL-6; salivary IL-17F and salivary, serum IL-17A/F levels were higher in the IU group than the H group (p<0.05). However, serum IL-10 and IL-17E levels were higher in the H group than the IU group (p<0.05). A. actinomycetemcomitans, F. nucleatum, S. oralis, A. naeslundi and V. dispar counts were higher in IU group compared to H group (p<0.05). Conclusion Altered local and systemic cytokine profiles are associated with differences in the microbial plaque composition in IU. Anti-inflammatory cytokines; IL-10, IL-17E are reduced in patients with IU and Th-1 and Th-17 driven inflammatory responses in biofluids are altered.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lappin, Dr David
Authors: Akcal, A., Yılmaz, S. G., Lappin, D. F., and Eğrilmez, S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Clinical Periodontology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0303-6979
ISSN (Online):1600-051X
Published Online:30 March 2016
Copyright Holders:Copyright © 2016 John Wiley and Sons
First Published:First published in Journal of Clinical Periodontology 2016
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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