APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds

Lyall, D. M. et al. (2015) APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke, 10(8), pp. 1297-1300. (doi: 10.1111/ijs.12615) (PMID:26310205)

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Abstract

Background: Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease. Aim and/or hypothesis: To test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 ‘523’ poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults. Methods: Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74). Results: No significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants. Conclusions: Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lyall, Dr Donald
Authors: Lyall, D. M., Muñoz Maniega, S., Harris, S. E., Bastin, M. E., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdés Hernández, M. d. C., Royle, N. A., Starr, J. M., Porteous, D. J., Deary, I. J., and Wardlaw, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:International Journal of Stroke
Publisher:Wiley
ISSN:1747-4930
ISSN (Online):1747-4949
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in International Journal of Stroke 10(8):1297-1300
Publisher Policy:Reproduced under a Creative Commons License

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