Signalling C-Type lectin receptors, microbial recognition and immunity

Hoving, J. C., Wilson, G. J. and Brown, G. D. (2014) Signalling C-Type lectin receptors, microbial recognition and immunity. Cellular Microbiology, 16(2), pp. 185-194. (doi: 10.1111/cmi.12249) (PMID:24330199) (PMCID:PMC4016756)

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Abstract

Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-inflammatory responses which are either protective or not during an infection. Understanding the role of CLRs in shaping anti-microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLRs in antifungal immunity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilson, Dr Gillian
Authors: Hoving, J. C., Wilson, G. J., and Brown, G. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley-Blackwell Publishing
ISSN:1462-5814
ISSN (Online):1462-5822
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Cellular Microbiology 16(2):185-194
Publisher Policy:Reproduced under a Creative Commons License

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