Chatzi, A., Manganas, P. and Tokatlidis, K. (2016) Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(6 Pt.A), pp. 1298-1306. (doi: 10.1016/j.bbamcr.2016.03.023) (PMID:27033519)
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Abstract
Mitochondria are fundamental organelles with a complex internal architecture that fulfill important diverse functions including iron–sulfur cluster assembly and cell respiration. Intense work for more than 30 years has identified the key protein import components and the pathways involved in protein targeting and assembly. More recently, oxidative folding has been discovered as one important mechanism for mitochondrial proteostasis whilst several human disorders have been linked to this pathway. We describe the molecular components of this pathway in view of their putative redox regulation and we summarize available evidence on the connections of these pathways to human disorders.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Manganas, Phanee and Tokatlidis, Professor Kostas and Chatzi, Ms Afroditi |
| Authors: | Chatzi, A., Manganas, P., and Tokatlidis, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Biochimica et Biophysica Acta: Molecular Cell Research |
| Publisher: | Elsevier |
| ISSN: | 0167-4889 |
| Published Online: | 28 March 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Biochimica et Biophysica Acta: Molecular Cell Research 1863(6, Pt. A):1298-1306 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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