Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease

Chatzi, A., Manganas, P. and Tokatlidis, K. (2016) Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(6 Pt.A), pp. 1298-1306. (doi: 10.1016/j.bbamcr.2016.03.023) (PMID:27033519)

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Abstract

Mitochondria are fundamental organelles with a complex internal architecture that fulfill important diverse functions including iron–sulfur cluster assembly and cell respiration. Intense work for more than 30 years has identified the key protein import components and the pathways involved in protein targeting and assembly. More recently, oxidative folding has been discovered as one important mechanism for mitochondrial proteostasis whilst several human disorders have been linked to this pathway. We describe the molecular components of this pathway in view of their putative redox regulation and we summarize available evidence on the connections of these pathways to human disorders.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Manganas, Phanee and Tokatlidis, Professor Kostas and Chatzi, Ms Afroditi
Authors: Chatzi, A., Manganas, P., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Biochimica et Biophysica Acta: Molecular Cell Research
Publisher:Elsevier
ISSN:0167-4889
Published Online:28 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Biochimica et Biophysica Acta: Molecular Cell Research 1863(6, Pt. A):1298-1306
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
624931Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.Konstantinos TokatlidisRoyal Society (ROYSOC)WM120111RI MOLECULAR CELL & SYSTEMS BIOLOGY