The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Southan, C. et al. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44(D1), D1054-D1068. (doi: 10.1093/nar/gkv1037) (PMID:26464438) (PMCID:PMC4702778)

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The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.

Item Type:Articles
Additional Information:IUPHAR; BPS; Wellcome Trust [099156]. Funding for open access: Wellcome Trust.
Glasgow Author(s) Enlighten ID:McGrath, Professor John
Authors: Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P.H., Buneman, O. P., Davenport, A. P., McGrath, J., Peters, J. A., Spedding, M., Catterall, W. A., Fabbro, D., and Davies, J. A.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Nucleic Acids Research
Publisher:Oxford University Press on behalf of Nucleic Acids Research
ISSN (Online):1362-4962
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Nucleic Acids Research 44:D1054-D1068
Publisher Policy:Reproduced under a creative commons license

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