Pre- and post-natal stress programming: developmental exposure to glucocorticoids causes long-term brain-region specific changes to transcriptome in the Japanese quail

Marasco, V., Herzyk, P. , Robinson, J. and Spencer, K. A. (2016) Pre- and post-natal stress programming: developmental exposure to glucocorticoids causes long-term brain-region specific changes to transcriptome in the Japanese quail. Journal of Neuroendocrinology, 28(5), (doi: 10.1111/jne.12387) (PMID:26999292) (PMCID:PMC5103168)

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Abstract

Exposure to stress during early development can permanently influence an individual's physiology and behavior, and affect its subsequent health. The extent to which elevated glucocorticoids cause such long-term “programming” remains largely untested. Here, using the Japanese quail as our study species, we independently manipulated exposure to corticosterone during pre- and/or post-natal development and investigated the subsequent effects on global gene expression profiles within the hippocampus and hypothalamus upon adulthood. Our results showed that the changes in transcriptome profiles in response to corticosterone exposure clearly differed between the hippocampus and the hypothalamus. We also showed that these effects depended on the developmental timing of exposure and identified brain-region specific gene expression patterns that were either (1) similarly altered by corticosterone regardless of the developmental stage in which hormonal exposure occurred, or (2) specifically and uniquely altered by either pre-natal or post-natal exposure to corticosterone. Corticosterone-treated birds showed alterations in networks of genes which included known markers of the programming actions of early life adversity (e.g. brain-derived neurotrophic factor, and mineralocorticoid receptor within the hippocampus; corticotropin-releasing hormone and serotonin receptors in the hypothalamus). Altogether, these findings provide for the first time experimental support to the hypothesis that exposure to elevated glucocorticoids during development may be a key hormonal signaling pathway through which the long-term phenotypic effects associated with early life adversity emerge and potentially persist throughout the lifespan. These data also highlight that stressors might have different long-lasting impacts on the brain transcriptome depending on the developmental stage in which they are experienced; more work is now required to relate these mechanisms to organismal phenotypic differences.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robinson, Dr Jane and Herzyk, Dr Pawel and Marasco, Dr Valeria and Spencer, Dr Karen
Authors: Marasco, V., Herzyk, P., Robinson, J., and Spencer, K. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Journal of Neuroendocrinology
Publisher:Wiley
ISSN:0953-8194
ISSN (Online):1365-2826
Published Online:25 May 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Neuroendocrinology 28(5)
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
451431Glucocorticoid programming in birds - mechanisms and consequencesKaren SpencerBiotechnology and Biological Sciences Research Council (BBSRC)BB/E024459/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED