Nuclear import of the influenza A virus transcriptional machinery

Hutchinson, E.C. and Fodor, E. (2012) Nuclear import of the influenza A virus transcriptional machinery. Vaccine, 30(51), pp. 7353-7358. (doi:10.1016/j.vaccine.2012.04.085) (PMID:22652398)

Full text not currently available from Enlighten.


Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hutchinson, Dr Edward
Authors: Hutchinson, E.C., and Fodor, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine
ISSN (Online):0264-410X

University Staff: Request a correction | Enlighten Editors: Update this record