Nuclear import of the influenza A virus transcriptional machinery

Hutchinson, E.C. and Fodor, E. (2012) Nuclear import of the influenza A virus transcriptional machinery. Vaccine, 30(51), pp. 7353-7358. (doi:10.1016/j.vaccine.2012.04.085) (PMID:22652398)

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Abstract

Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hutchinson, Dr Edward
Authors: Hutchinson, E.C., and Fodor, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Vaccine
Publisher:Elsevier
ISSN:0264-410X
ISSN (Online):0264-410X

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