Transport of the influenza virus genome from nucleus to nucleus

Hutchinson, E. C. and Fodor, E. (2013) Transport of the influenza virus genome from nucleus to nucleus. Viruses, 5(10), pp. 2424-2446. (doi:10.3390/v5102424) (PMID:24104053) (PMCID:PMC3814596)

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The segmented genome of an influenza virus is encapsidated into ribonucleoprotein complexes (RNPs). Unusually among RNA viruses, influenza viruses replicate in the nucleus of an infected cell, and their RNPs must therefore recruit host factors to ensure transport across a number of cellular compartments during the course of an infection. Recent studies have shed new light on many of these processes, including the regulation of nuclear export, genome packaging, mechanisms of virion assembly and viral entry and, in particular, the identification of Rab11 on recycling endosomes as a key mediator of RNP transport and genome assembly. This review uses these recent gains in understanding to describe in detail the journey of an influenza A virus RNP from its synthesis in the nucleus through to its entry into the nucleus of a new host cell.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hutchinson, Dr Edward
Authors: Hutchinson, E. C., and Fodor, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:M D P I AG
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Viruses 5(10):2424-2446
Publisher Policy:Reproduced under a Creative Commons License

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