The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

McInnes, I. B. , Al-Mughales, J., Field, M., Leung, B. P., Huang, F.-p., Dixon, R., Sturrock, R. D., Wilkinson, P. C. and Liew, F. Y. (1996) The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis. Nature Medicine, 2(2), pp. 175-182. (doi:10.1038/nm0296-175) (PMID:8574962)

Full text not currently available from Enlighten.

Abstract

Interleukin 15 (IL−15) is a novel cytokine with interleukin−2−like activity. It is also a potent T−lymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the presence of activated T lymphocytes, macrophages and synoviocytes in the synovial membrane. The mechanisms of T−cell activation in RA are currently unclear. We report the presence of high concentrations of IL−15 in rheumatoid arthritis (RA) synovial fluid and have demonstrated its expression in the synovial membrane lining layer by immunohistochemistry. RA synovial fluids were found to contain chemotactic activity, which was attributable in part to the presence of IL−15. Moreover, in a murine model, injection of recombinant IL−15 was found to induce a local tissue inflammatory infiltrate consisting predominantly of T lymphocytes. Synovial fluid T lymphocytes proliferate in response to IL−15, demonstrating that continued responsiveness to IL−15 is a feature of T cells after entry into the synovial compartment. These data suggest that IL−15 can recruit and activate T lymphocytes into the synovial membrane, thereby contributing to RA pathogenesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liew, Professor Foo and McInnes, Professor Iain and Sturrock, Professor Roger and Field, Dr Max and Leung, Dr Bernard
Authors: McInnes, I. B., Al-Mughales, J., Field, M., Leung, B. P., Huang, F.-p., Dixon, R., Sturrock, R. D., Wilkinson, P. C., and Liew, F. Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nature Medicine
Publisher:Nature Publishing Group
ISSN:1078-8956
ISSN (Online):1546-170X

University Staff: Request a correction | Enlighten Editors: Update this record