Lack of effect of TNFα blockade therapy on circulating adiponectin levels in patients with autoimmune disease: results from two independent prospective studies

Peters, M. J. L., Watt, P., Cherry, L., Welsh, P. , Henninger, E., Dijkmans, B. A. C., McInnes, I. B. , Nurmohamed, M. T. and Sattar, N. (2010) Lack of effect of TNFα blockade therapy on circulating adiponectin levels in patients with autoimmune disease: results from two independent prospective studies. Annals of the Rheumatic Diseases, 69(9), pp. 1687-1690. (doi:10.1136/ard.2009.114207) (PMID:19640853)

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Abstract

Background: Adiponectin is an anti-inflammatory and potentially antiatherogenic molecule. Some recent reports suggest that tumour necrosis factor α (TNFα) blockade therapy increases circulating adiponectin levels, but data are sparse and inconsistent. Methods: Data from a double-blind placebo controlled study of onercept in 126 patients with psoriatic arthritis (PsA) and from pre- and post-adalimumab treatment in 171 patients with rheumatoid arthritis (RA) were used to examine the effect of TNFα blockade therapy on adiponectin. Results: Despite expected associations of adiponectin with gender and baseline high-density lipoprotein cholesterol and triglyceride, adiponectin levels did not change over time with TNFα blockade therapy in either group. The mean±SD absolute change in adiponectin levels was −0.23±4.6 μg/ml in patients with PsA treated with combined onercept 50 mg and onercept 100 mg (vs placebo, p=0.60) and 0.28±3.23 μg/ml in patients with RA treated with adalimumab (vs baseline, p=0.66). Conclusion: These results do not support a significant effect of TNFα blockade therapy on circulating adiponectin levels in patients with autoimmune disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Watt, Miss Pauline and Welsh, Dr Paul and Cherry, Mrs Lynne and Sattar, Professor Naveed
Authors: Peters, M. J. L., Watt, P., Cherry, L., Welsh, P., Henninger, E., Dijkmans, B. A. C., McInnes, I. B., Nurmohamed, M. T., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Annals of the Rheumatic Diseases
Publisher:B M J Group
ISSN:0003-4967
ISSN (Online):1468-2060

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