Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study

Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M., Stewart, W. , Condon, B., Muir, K.W. , Welch, G. and Forbes, K.P. (2016) Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study. Journal of Neuroimaging, 26(4), pp. 406-413. (doi:10.1111/jon.12332) (PMID:26919134)

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Abstract

Background and Purpose Carotid artery atherosclerotic plaque composition may influence plaque stability and risk of thromboembolic events, and non-invasive plaque imaging may therefore permit risk stratification for clinical management. Plaque composition was compared using non-invasive in-vivo (3T) and ex-vivo (7T) MRI and histopathological examination. Methods Thirty three endarterectomy cross sections, from 13 patients, were studied. The datasets consisted of in-vivo 3T MRI, ex-vivo 7T MRI and histopathology. Semi-automated segmentation methods were used to measure areas of different plaque components. Bland- Altman plots and mean difference with 95% confidence interval were carried out. Results There was general quantitative agreement between areas derived from semi-automated segmentation of MRI data and histology measurements. The mean differences and 95% confidence bounds in the relative to total plaque area between 3T versus Histology were: fibrous tissue 4.99 % (-4.56 to 14.56), lipid-rich/necrotic core (LR/NC) with haemorrhage - 1.81% (-14.11 to 10.48), LR/NC without haemorrhage -2.43% (-13.04 to 8.17), and calcification -3.18% (-11.55 to 5.18). The mean differences and 95% confidence bounds in the relative to total plaque area between 7T and histology were: fibrous tissue 3.17 % (-3.17 to 9.52), LR/NC with haemorrhage -0.55% (-9.06 to 7.95), LR/NC without haemorrhage - 12.62% (-19.8 to -5.45), and calcification -2.43% (-9.97 to 4.73). Conclusions This study provides evidence that semi-automated segmentation of 3T/7T MRI techniques can help to determine atherosclerotic plaque composition. In particular, the high resolution of ex-vivo 7T data was able to highlight greater detail in the atherosclerotic plaque composition. High field MRI may therefore have advantages for in vivo carotid plaque MR imaging.

Item Type:Articles
Additional Information:This is the peer reviewed version of the following article: Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M., Stewart, W., Muir, K.W., Condon, B., Welch, G. and Forbes, K.P. (2016), Atherosclerotic Carotid Plaque Composition: A 3T and 7T MRI-Histology Correlation Study. Journal of Neuroimaging. doi: 10.1111/jon.12332, which has been published in final form at [10.1111/jon.12332]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stewart, Dr William and Welch, Mr George and Condon, Professor Barrie and Holmes, Dr William and Muir, Professor Keith and Lopez Gonzalez, Dr Maria Del and Forbes, Dr Kirsten
Authors: Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M., Stewart, W., Condon, B., Muir, K.W., Welch, G., and Forbes, K.P.
Subjects:Q Science > QC Physics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Neuroimaging
Publisher:Wiley
ISSN:1051-2284
ISSN (Online):1552-6569
Published Online:25 February 2016
Copyright Holders:Copyright © 2016 American Society of Neuroimaging
First Published:First published in Journal of Neuroimaging 26(4): 406-413
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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