Causal evidence that intrinsic beta-frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS

Romei, V., Bauer, M., Brooks, J. L., Economides, M., Penny, W., Thut, G. , Driver, J. and Bestmann, S. (2016) Causal evidence that intrinsic beta-frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS. NeuroImage, 126, pp. 120-130. (doi: 10.1016/j.neuroimage.2015.11.020) (PMID:26584867) (PMCID:PMC4739512)

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Abstract

Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta peak frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency. Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thut, Professor Gregor
Authors: Romei, V., Bauer, M., Brooks, J. L., Economides, M., Penny, W., Thut, G., Driver, J., and Bestmann, S.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:NeuroImage
Publisher:Elsevier
ISSN:1053-8119
ISSN (Online):1095-9572
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in NeuroImage 126:120-130
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597911Natural and modulated neural communication: State-dependent decoding and driving of human Brain OscillationsGregor ThutWellcome Trust (WELLCOME)098434/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING