Native myocardial longitudinal (T1) relaxation time: Regional, age, and sex associations in the healthy adult heart

Rauhalammi, S. M.O., Mangion, K., Barrientos, P. H., Carrick, D. J.A., Clerfond, G., McClure, J., McComb, C., Radjenovic, A. and Berry, C. (2016) Native myocardial longitudinal (T1) relaxation time: Regional, age, and sex associations in the healthy adult heart. Journal of Magnetic Resonance Imaging, 44(3), pp. 541-548. (doi:10.1002/jmri.25217) (PMID:26946323) (PMCID:PMC5025725)

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Abstract

Purpose: To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods: In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look–Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results: In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion: In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016.

Item Type:Articles
Additional Information:This research was supported by a Project Grants from the Chief Scientist Office (SC01), Medical Research Scotland (343 FRG) and the British Heart Foundation (BHF-PG/14/64/31043). Dr Mangion is supported by a Fellowship from the British Heart Foundation (FS/15/54/31639).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Clerfond, Dr Guillaume and Mccomb, Dr Christie and Mangion, Dr Kenneth and Carrick, Dr David and McClure, Dr John and Radjenovic, Dr Aleksandra
Authors: Rauhalammi, S. M.O., Mangion, K., Barrientos, P. H., Carrick, D. J.A., Clerfond, G., McClure, J., McComb, C., Radjenovic, A., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Magnetic Resonance Imaging
Publisher:Wiley
ISSN:1053-1807
ISSN (Online):1522-2586
Published Online:04 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Magnetic Resonance Imaging 44(3):541-548
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
662681"First steps towards modelling myocardial infarction (a computed MI Physiome): A case-control study of novel biomechanical parameters in acute MI survivors with left ventricular dysfunction."Colin BerryBritish Heart Foundation (BHF)PG/14/64/31043RI CARDIOVASCULAR & MEDICAL SCIENCES
699321Myocardial strain measurements in survivors of acute ST-elevation myocardial infarction: implementation and prognostic significance of novel magnetic resonance imaging methods.Colin BerryBritish Heart Foundation (BHF)FS/15/54/31639RI CARDIOVASCULAR & MEDICAL SCIENCES
525991Cardiac magnetic resonance imaging: new pathological insights and functional significance in acute myocardial infarctionColin BerryMedical Research Scotland (MED-SCOT)343 FRG FRI CARDIOVASCULAR & MEDICAL SCIENCES