Rauhalammi, S. M.O., Mangion, K., Barrientos, P. H., Carrick, D. J.A., Clerfond, G., McClure, J. , McComb, C., Radjenovic, A. and Berry, C. (2016) Native myocardial longitudinal (T1) relaxation time: Regional, age, and sex associations in the healthy adult heart. Journal of Magnetic Resonance Imaging, 44(3), pp. 541-548. (doi: 10.1002/jmri.25217) (PMID:26946323) (PMCID:PMC5025725)
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Abstract
Purpose: To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods: In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look–Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results: In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion: In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016.
| Item Type: | Articles |
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| Additional Information: | This research was supported by a Project Grants from the Chief Scientist Office (SC01), Medical Research Scotland (343 FRG) and the British Heart Foundation (BHF-PG/14/64/31043). Dr Mangion is supported by a Fellowship from the British Heart Foundation (FS/15/54/31639). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mccomb, Dr Christie and Carrick, Dr David and Clerfond, Dr Guillaume and Mangion, Dr Kenneth and Berry, Professor Colin and McClure, Dr John and Radjenovic, Dr Aleksandra |
| Authors: | Rauhalammi, S. M.O., Mangion, K., Barrientos, P. H., Carrick, D. J.A., Clerfond, G., McClure, J., McComb, C., Radjenovic, A., and Berry, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Magnetic Resonance Imaging |
| Publisher: | Wiley |
| ISSN: | 1053-1807 |
| ISSN (Online): | 1522-2586 |
| Published Online: | 04 March 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Journal of Magnetic Resonance Imaging 44(3):541-548 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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