Study of cardiovascular function using a coupled left ventricle and systemic circulation model

Chen, W.W., Gao, H. , Luo, X.Y. and Hill, N.A. (2016) Study of cardiovascular function using a coupled left ventricle and systemic circulation model. Journal of Biomechanics, 49(12), pp. 2445-2454. (doi:10.1016/j.jbiomech.2016.03.009) (PMID:27040388) (PMCID:PMC5038162)

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Abstract

To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV–SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the systemic arteries (SA). The coupling of the LV model and the SA model is achieved by matching the pressure and the flow rate at the aortic root, i.e. the SA model feeds back the pressure as a boundary condition to the LV model, and the aortic flow rate from the LV model is used as the input for the SA model. The governing equations of the coupled system are solved using a combined immersed-boundary finite-element (IB/FE) method and a Lax–Wendroff scheme. A baseline case using physiological measurements of healthy subjects, and four exemplar cases based on different physiological and pathological scenarios are studied using the LV–SA model. The results of the baseline case agree well with published experimental data. The four exemplar cases predict varied pathological responses of the cardiovascular system, which are also supported by clinical observations. The new model can be used to gain insight into cardio-arterial interactions across a range of clinical applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Hill, Professor Nicholas and Gao, Dr Hao and Chen, WeiWei
Authors: Chen, W.W., Gao, H., Luo, X.Y., and Hill, N.A.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Biomechanics
Publisher:Elsevier
ISSN:0021-9290
ISSN (Online):1873-2380
Published Online:18 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Biomechanics 49(12):2445-2454
Publisher Policy:Reproduced under a Creative Commons License
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