The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: a systematic review and meta-analysis

McSorley, S. T. , Horgan, P. G. and McMillan, D. C. (2016) The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 97, pp. 168-177. (doi:10.1016/j.critrevonc.2015.08.013) (PMID:26330375)

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Abstract

Background: This systematic review investigated the impact of complications by type (infective vs. non-infective) and severity (using the Clavien Dindo scale) on long-term outcome following surgery for colorectal cancer. Methods: A systematic review was performed using appropriate keywords. Meta-analysis using a random effects model was performed. Results: 14 studies were included with a total 18,611 patients. Infective complications had a significant impact on disease free (HR 1.41, 95%CI 1.08–1.83, p = 0.01) and overall survival (1.37 95%CI 1.22–1.55, p < 0.001). Non-infective complications had no significant impact on either disease free (HR 1.21, 95%CI 0.97–1.52, p = 0.09) or overall survival (HR 1.35, 95%CI 0.92–1.97, p = 0.12). Complication severity had a significant impact on both disease free (HR 1.41, 95%CI 1.18–1.68, p < 0.001) and overall survival (HR 1.45, 95%CI 1.25–1.69, p < 0.001). Discussion: Both type and severity of postoperative complications have an impact on long-term survival following surgery for colorectal cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Horgan, Professor Paul and McMillan, Professor Donald and McSorley, Dr Stephen
Authors: McSorley, S. T., Horgan, P. G., and McMillan, D. C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Critical Reviews in Oncology/Hematology
Publisher:Elsevier
ISSN:1040-8428
ISSN (Online):1879-0461
Copyright Holders:Copyright © 2015 Elsevier
First Published:First published in Critical Reviews in Oncology Hematology 97:168-177
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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