McSorley, S. T. , Horgan, P. G. and McMillan, D. C. (2016) The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 97, pp. 168-177. (doi: 10.1016/j.critrevonc.2015.08.013) (PMID:26330375)
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Abstract
Background: This systematic review investigated the impact of complications by type (infective vs. non-infective) and severity (using the Clavien Dindo scale) on long-term outcome following surgery for colorectal cancer. Methods: A systematic review was performed using appropriate keywords. Meta-analysis using a random effects model was performed. Results: 14 studies were included with a total 18,611 patients. Infective complications had a significant impact on disease free (HR 1.41, 95%CI 1.08–1.83, p = 0.01) and overall survival (1.37 95%CI 1.22–1.55, p < 0.001). Non-infective complications had no significant impact on either disease free (HR 1.21, 95%CI 0.97–1.52, p = 0.09) or overall survival (HR 1.35, 95%CI 0.92–1.97, p = 0.12). Complication severity had a significant impact on both disease free (HR 1.41, 95%CI 1.18–1.68, p < 0.001) and overall survival (HR 1.45, 95%CI 1.25–1.69, p < 0.001). Discussion: Both type and severity of postoperative complications have an impact on long-term survival following surgery for colorectal cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Horgan, Professor Paul and McMillan, Professor Donald and McSorley, Dr Stephen |
| Authors: | McSorley, S. T., Horgan, P. G., and McMillan, D. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Critical Reviews in Oncology/Hematology |
| Publisher: | Elsevier |
| ISSN: | 1040-8428 |
| ISSN (Online): | 1879-0461 |
| Copyright Holders: | Copyright © 2015 Elsevier |
| First Published: | First published in Critical Reviews in Oncology Hematology 97:168-177 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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