Vacuolar protein sorting mechanisms in apicomplexan parasites

Jimenez Ruiz, E. , Morlong-Guyot, J., Daher, W. and Meissner, M. (2016) Vacuolar protein sorting mechanisms in apicomplexan parasites. Molecular and Biochemical Parasitology, 209(1-2), pp. 18-25. (doi:10.1016/j.molbiopara.2016.01.007) (PMID:26844642) (PMCID:PMC5154328)

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Abstract

The phylum Apicomplexa comprises more than 5000 species including pathogens of clinical and economical importance. These obligate intracellular parasites possess a highly complex endomembrane system to build amongst others three morphologically distinct secretory organelles: rhoptries, micronemes and dense granules. Proteins released by these organelles are essential for invasion and hijacking of the host cell. Due to the complexity of the internal organization of these parasites, a wide panoply of trafficking factors was expected to be required for the correct sorting of proteins towards the various organelles. However, Toxoplasma gondii and other apicomplexan parasites contain only a core set of these factors and several of the vacuolar protein sorting (VPS) homologues found in most eukaryotes have been lost in this phylum. In this review, we will summarise our current knowledge about the role of trafficking complexes in T. gondii, highlighting recent studies focused on complexes formed by VPS proteins. We also present a novel, hypothetical model, suggesting the recycling of parasite membrane and micronemal proteins.

Item Type:Articles
Additional Information:This work was supported by an ERC-Starting grant (ERC-2012-StG 309255-EndoTox) and the Wellcome Trust 087582/Z/08/Z Senior Fellowship for M.M. The Wellcome Trust Centre for Molecular Parasitology is supported by core funding from the Wellcome Trust (085349). Drs Wassim DAHER and Juliette Morlon-Guyot are INSERM researchers
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meissner, Professor Markus and Jimenez Ruiz, Dr Elena
Authors: Jimenez Ruiz, E., Morlong-Guyot, J., Daher, W., and Meissner, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN:0166-6851
ISSN (Online):1872-9428
Published Online:01 February 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Molecular and Biochemical Parasitology 209(1-2):18-25
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
501602Systematic analysis of essential parasite genes linked to invasion of the host cell in Toxoplasma gondiiMarkus MeissnerWellcome Trust (WELLCOME)087582/Z/08/ZIII - PARASITOLOGY