Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension

Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi:10.1007/978-1-4615-5385-4_3) (PMID:9433508)

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Abstract

Hypertensive left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality in human essential hypertension. It has been shown that LVH is a better predictor of coronary artery disease and stroke than high blood pressure itself, hyperlipidaemia and cigarette smoking1,2. The spontaneously hypertensive rat (SHR) and its close relative stroke-prone SHR (SHRSP) have been used as models of hypertensive LVH and have allowed us to develop a number of mechanistic and genetic studies which would not have been feasible in human essential hypertension.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Dr Delyth and Hamilton, Dr Carlene and Dominiczak, Professor Anna and McPhaden, Dr Allan and Reid, Professor John
Authors: Dominiczak, A. F., Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D., Clark, J. S., McPhaden, A., Hamilton, C. A., and Reid, J. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO Unit
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Advances in Experimental Medicine and Biology
Publisher:Springer New York
ISSN:0065-2598

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