Gong, Y. et al. (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension, 33(11), pp. 2278-2285. (doi: 10.1097/hjh.0000000000000714) (PMID:26425837)
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Abstract
Objective: The aim of this study is to identify single-nucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the [beta]-blocker atenolol. Methods: Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10-5 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n = 2114). Results: In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P = 3.2 × 10-6 and P = 5.9 × 10-6, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P = 0.0018 and P = 0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P = 8.25 × 10-6). rs12346562 had a similar trend in association with response to bisoprolol (a different [beta]-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P = 3.2 × 10-5). Conclusion: PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh |
Authors: | Gong, Y., McDonough, C. W., Beitelshees, A. L., Rouby, N. E., Hiltunen, T. P., O’Connell, J. R., Padmanabhan, S., Langaee, T. Y., Hall, K., Schmidt, S. O.F., Curry, R. W., Gums, J. G., Donner, K. M., Kontula, K. K., Bailey, K. R., Boerwinkle, E., Takahashi, A., Tanaka, T., Kubo, M., Chapman, A. B., Turner, S. T., Pepine, C. J., Cooper-DeHoff, R. M., and Johnson, J. A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Hypertension |
Publisher: | Lippincott Williams & Wilkins |
ISSN: | 0263-6352 |
ISSN (Online): | 1473-5598 |
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