Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction

Ayoub, A. , Challa, S.R.R., Abu-Serriah, M., McMahon, J., Moos, K., Creanor, S. and Odell, E. (2007) Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction. International Journal of Oral and Maxillofacial Surgery, 36(12), pp. 1183-1192. (doi: 10.1016/j.ijom.2007.07.012) (PMID:17822878)

Abstract

The aim of this study was to investigate the feasibility of reconstructing critical size continuity osteoperiosteal defects of the mandible using a composite of recombinant BMP-7 contained in a bovine type-1 collagen carrier wrapped in a pedicled sterno-occipitalis muscle flap. At 3 months following surgery, bridging of the surgical defect was noted in three subjects (60%). Histologically, the induced bone regenerate showed maturation from woven to lamellar bone. Islands of cartilage were distributed throughout the defect. Replacement ossification of the degenerated muscle was a common feature in all specimens. Microradiography showed a gradual increase in the calcification of mineralized tissue from the margin to the centre of the newly generated bone. This research represents a proof of the concept that bone can be satisfactorily formed within a muscular scaffolding at the site of the created defect in a one-stage procedure.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Moos, Professor Khursheed and Ayoub, Professor Ashraf and Creanor, Dr Stephen and McMahon, Dr Jeremy
• Authors: Ayoub, A., Challa, S.R.R., Abu-Serriah, M., McMahon, J., Moos, K., Creanor, S., and Odell, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: International Journal of Oral and Maxillofacial Surgery
• Publisher: Elsevier
• ISSN: 0901-5027
• ISSN (Online): 1399-0020