On being the right size: increased body size is associated with reduced telomere length under natural conditions

Ringsby, T. H. et al. (2015) On being the right size: increased body size is associated with reduced telomere length under natural conditions. Proceedings of the Royal Society of London Series B: Biological Sciences, 282(1820), p. 20152331. (doi:10.1098/rspb.2015.2331) (PMID:26631569)

Ringsby, T. H. et al. (2015) On being the right size: increased body size is associated with reduced telomere length under natural conditions. Proceedings of the Royal Society of London Series B: Biological Sciences, 282(1820), p. 20152331. (doi:10.1098/rspb.2015.2331) (PMID:26631569)

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Abstract

Evolution of body size is likely to involve trade-offs between body size, growth rate and longevity. Within species, larger body size is associated with faster growth and ageing, and reduced longevity, but the cellular processes driving these relationships are poorly understood. One mechanism that might play a key role in determining optimal body size is the relationship between body size and telomere dynamics. However, we know little about how telomere length is affected when selection for larger size is imposed in natural populations. We report here on the relationship between structural body size and telomere length in wild house sparrows at the beginning and end of a selection regime for larger parent size that was imposed for 4 years in an isolated population of house sparrows. A negative relationship between fledgling size and telomere length was present at the start of the selection; this was extended when fledgling size increased under the selection regime, demonstrating a persistent covariance between structural size and telomere length. Changes in telomere dynamics, either as a correlated trait or a consequence of larger size, could reduce potential longevity and the consequent trade-offs could thereby play an important role in the evolution of optimal body size.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Monaghan, Professor Patricia and Gillespie, Mr Robert and Boner, Dr Winifred
Authors: Ringsby, T. H., Jensen, H., Pärn, H., Kvalnes, T., Boner, W., Gillespie, R., Holand, H., Hagen, I. J., Rønning, B., Sæther, B.-E., and Monaghan, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Proceedings of the Royal Society of London Series B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8452
ISSN (Online):1471-2954
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Proceedings of the Royal Society of London Series B: Biological Sciences 282(1820): 20152331
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
545091ECOTELO - The ecological significance of telomere dynamics:environments, individuals and inheritancePatricia MonaghanEuropean Research Council (ERC)20100317/FP7-26RI BIODIVERSITY ANIMAL HEALTH & COMPMED