Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, M. S. et al. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 8658. (doi:10.1038/ncomms9658) (PMID:26635082) (PMCID:PMC4686825)

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Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Professor Neil and Padmanabhan, Professor Sandosh
Authors: Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M.’e., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M., Marten, J., Enroth, S., Surakka, I., Polasek, O., Lyytikäinen, L.-P., Granell, R., Hysi, P. G., Flexeder, C., Mahajan, A., Beilby, J., Bossé, Y., Brandsma, C.-A., Campbell, H., Gieger, C., Gläser, S., González, J. R., Grallert, H., Hammond, C. J., Harris, S. E., Hartikainen, A.-L., Heliövaara, M., Henderson, J., Hocking, L., Horikoshi, M., Hutri-Kähönen, N., Ingelsson, E., Johansson, Å., Kemp, J. P., Kolcic, I., Kumar, A., Lind, L., Melén, E., Musk, A. W., Navarro, P., Nickle, D. C., Padmanabhan, S., Raitakari, O. T., Ried, J. S., Ripatti, S., Schulz, H., Scott, R. A., Sin, D. D., Starr, J. M., Deloukas, P., Hansell, A. L., Hubbard, R., Jackson, V. E., Marchini, J., Pavord, I., Thomson, N., Zeggini, E., Viñuela, A., Völzke, H., Wild, S. H., Wright, A. F., Zemunik, T., Jarvis, D. L., Spector, T. D., Evans, D. M., Lehtimäki, T., Vitart, V., Kähönen, M., Gyllensten, U., Rudan, I., Deary, I. J., Karrasch, S., Probst-Hensch, N. M., Heinrich, J., Stubbe, B., Wilson, J. F., Wareham, N. J., James, A. L., Morris, A. P., Jarvelin, M.-R., Hayward, C., Sayers, I., Strachan, D. P., Hall, I. P., and Tobin, M. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Nature Communications 6:8658
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
381721Generation ScotlandAnna DominiczakScottish Executive Health Department (SEHHD-CSO)CZD/16/6RI CARDIOVASCULAR & MEDICAL SCIENCES