A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial Protocol (ADAPT)

Gumley, A. et al. (2016) A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial Protocol (ADAPT). Psychosis, 8(2), pp. 143-155. (doi: 10.1080/17522439.2015.1100669)

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Abstract

Background: Depression is one of the major contributors to poorer quality of life among individuals with psychosis and schizophrenia. Aims: This study protocol was designed as a pilot trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression. Methods: The study protocol was registered before initiating recruitment and was designed as a Parallel-group Randomised Open Blinded Evaluation (PROBE) comparing ACTdp plus standard care (SC) or SC alone. Participants were required to meet DSM-IV-TR criteria for schizophrenia and major depression (confirmed by Structured Clinical Interview for DSM/SCID-I and Calgary Depression Scale for Schizophrenia; score > 7). Blinded follow-ups are undertaken at 5 months (end of treatment) and at 10 months (5 months post treatment). Implications: The pilot aims to establish the basis for a larger-scale multi-centre randomised controlled trial of ACTdp. The most important study outcomes that will provide the basis of informing progression to a full trial are identified a priori as Population, Intervention, Control and Outcomes (PICO).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:White, Dr Ross and Stewart, Dr Corinna and Macleod, Dr Rachel and McLeod, Professor Hamish and Clarke, Miss Caoimhe and Barry, Dr Sarah and Ford, Professor Ian and Lidstone, Dr Emma and Beedie, Dr Sara and Briggs, Professor Andrew and Gumley, Professor Andrew
Authors: Gumley, A., White, R., Briggs, A., Ford, I., Barry, S., Stewart, C., Beedie, S., Clarke, C., Macleod, R., Lidstone, E., Nam, J., and McLeod, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Psychosis
Publisher:Taylor and Francis (Routledge)
ISSN:1752-2439
ISSN (Online):1752-2447
Published Online:28 October 2015

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
579891A Parallel group Randomised Open Blinded Evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial (ADAPT)Andrew GumleyScottish Executive Health Department (SEHHD-CSO)CZH/4/743IHW - MENTAL HEALTH & WELLBEING